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Malware homology identification based on a gene perspective Research Papers

Bing-lin ZHAO, Zheng SHAN, Fu-dong LIU, Bo ZHAO, Yi-hang CHEN, Wen-jie SUN

Frontiers of Information Technology & Electronic Engineering 2019, Volume 20, Issue 6,   Pages 801-815 doi: 10.1631/FITEE.1800523

Abstract: In response to these problems, we propose a new malware homology identification method from a gene perspectiveA malware gene is represented by the subgraph, which can describe the homology of malware families.We extract the key subgraph from the function dependency graph as the malware gene by selecting the keyThen, we encode the gene and design a frequent subgraph mining algorithm to find the common genes between

Keywords： Malware classification     Gene perspective     Dependency graph     Homology analysis    

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A new perspective in pyroptosis: lifting the veil on GSDMA activation

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 581-583 doi: 10.1007/s11684-022-0971-9

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INDIAN PERSPECTIVE: SUSTAINABILITY OF BT COTTON IS A MATTER OF CONCERN NOW!

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1,   Pages 146-149 doi: 10.15302/J-FASE-2021415

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Applying an Integrated Systems Perspective to the Management of Engineering Projects

Simon P. Philbin

Frontiers of Engineering Management 2015, Volume 2, Issue 1,   Pages 19-30 doi: 10.15302/J-FEM-2015004

Abstract: Consequently, a management framework has been developed that is based on an integrated systems perspective

Keywords： integrated systems perspective     engineering projects     management    

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Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Strategic Study of CAE 2000, Volume 2, Issue 11,   Pages 1-11

Abstract:

In this paper, the study on family collection, gene mapping, gene identification and gene functiont (1; 3) (q44; p11) associated with nasopharyngeal cancer was found in 1975 at first, and human TDF geneIn 1998, GJB3, a human genetic neurological deafness gene, was identified using a novel strategy of “Gene Family-Candidate Disease Gene Cloning”，and the paper was published in Nature Geneticswas also cloned from gene function study.

Keywords： genetic disease     gene mapping and cloning     gene familiy-candidate disease gene cloning     genome wide scan     gene function study    

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Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 663-675 doi: 10.1007/s11705-017-1623-5

Abstract: Small interfering RNA (siRNA) therapeutics hold great promise to treat a variety of diseases, as long as they can be delivered safely and effectively into cells. Dendrimers are appealing vectors for siRNA delivery by virtue of their well-defined molecular architecture and multivalent cooperativity. However, the clinical translation of RNA therapeutics mediated by dendrimer delivery is hampered by the lack of dendrimers that are of high quality to meet good manufacturing practice standard. In this context, we have developed small amphiphilic dendrimers that self-assemble into supramolecular structures, which mimic high-generation dendrimers synthesized with covalent construction, yet are easy to produce in large amount and superior quality. Indeed, the concept of supramolecular dendrimers has proved to be very promising, and has opened up a new avenue for dendrimer-mediated siRNA delivery. A series of self-assembling supramolecular dendrimers have consequently been established, some of them out-performing the currently available nonviral vectors in delivering siRNA to various cell types and , including human primary cells and stem cells. This short review presents a brief introduction to RNAi therapeutics, the obstacles to their delivery and the advantages of dendrimer delivery vectors as well as our bio-inspired structurally flexible dendrimers for siRNA delivery. We then highlight our efforts in creating self-assembling amphiphilic dendrimers to construct supramolecular dendrimer nanosystems for effective siRNA delivery as well as the related structural alterations to enhance delivery efficiency. The advent of self-assembling supramolecular dendrimer nanovectors holds great promise and heralds a new era of dendrimer-mediated delivery of RNA therapeutics in biomedical applications.

Keywords： gene therapy     RNAi therapeutics     dendrimer     nanovectors     gene silencing    

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Comments on the development of blockchain technology from the perspective of patent analysis

Wenhong LI, Chunxiao FU, Deli CHENG

Frontiers of Engineering Management 2020, Volume 7, Issue 4,   Pages 615-617 doi: 10.1007/s42524-020-0101-9

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The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 161-168 doi: 10.1007/s11684-017-0531-x

Abstract: We propose that the resistance gene flow in nature is “from the natural environments” andand animals, as intermediate recipients and disseminators, contribute greatly to such a resistance gene

Keywords： antibiotic resistance     resistome     microbiome     gene flow    

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Reflections on the system of evaluation of gene-edited livestock

Ziyao FAN, Tianwen WU, Kui WU, Yulian MU, Kui LI

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 211-217 doi: 10.15302/J-FASE-2019303

Abstract: functions regarding economic traits, and new materials for livestock breeding have been obtained through geneEvaluation is the most important component of the regulation of gene-edited livestock and is a crucialguarantee of public safety before the marketing of gene-edited animal products.Here, the system of evaluation of gene-edited livestock is discussed in terms of public safety and production

Keywords： evaluation     gene editing     livestock     performance     safety    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Then, based on RNA-seq data from The Cancer Genome Atlas AML cohort, we developed a 300-gene signatureThis study revealed the distinct gene expression pattern of RUNX1 mutations and the underlying

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain

Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 141-147 doi: 10.1007/s11684-009-0041-6

Abstract: To explore the possibility of Rab9-related gene therapy for neurodegenerative diseases, we packed LentivirusWestern blotting revealed that the Rab9 gene expression in BALB/c mice brain was up-regulated significantlyLentivirus encoding Rab9 can increase the expression of Rab9 gene effectively, which might offer a novel

Keywords： Rab9     lentivirus     gene therapy     gene transfer    

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Contributions in renewable energy systems: A perspective from the latest publications of FCSE

Xiaowen Zhu, Di Xu, Jing-Kang Wang

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 4,   Pages 632-635 doi: 10.1007/s11705-019-1904-2

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Photoaging mechanism of microplastics: a perspective on the effect of dissolved organic matter in natural

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 11, doi: 10.1007/s11783-023-1743-8

Abstract:

● Microplastics (MPs) undergo photoaging in natural water under light irradiation.

Keywords： Microplastics     Photoaging     Dissolved organic matter     ROS generation    

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A PDEM-based perspective to engineering reliability: From structures to lifeline networks

Jie LI

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 5,   Pages 1056-1065 doi: 10.1007/s11709-020-0636-1

Abstract: Research of reliability of engineering structures has experienced a developing history for more than 90 years. However, the problem of how to resolve the global reliability of structural systems still remains open, especially the problem of the combinatorial explosion and the challenge of correlation between failure modes. Benefiting from the research of probability density evolution theory in recent years, the physics-based system reliability researches open a new way for bypassing this dilemma. The present paper introduces the theoretical foundation of probability density evolution method in view of a broad background, whereby a probability density evolution equation for probability dissipative system is deduced. In conjunction of physical equations and structural failure criteria, a general engineering reliability analysis frame is then presented. For illustrative purposes, several cases are studied which prove the value of the proposed engineering reliability analysis method.

Keywords： PDEM     reliability     structure     lifeline networks    

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Current challenge and perspective of PGM-free cathode catalysts for PEM fuel cells

Gang WU

Frontiers in Energy 2017, Volume 11, Issue 3,   Pages 286-298 doi: 10.1007/s11708-017-0477-3

Abstract: To significantly reduce the cost of proton exchange membrane fuel cells, platinum-group metal (PGM)-free cathode catalysts are highly desirable. Current M-N-C (M: Fe, Co or Mn) catalysts are considered the most promising due to their encouraging performance. The challenge thus has been their stability under acidic conditions, which has hindered their use for any practical applications. In this review, based on the author’s research experience in the field for more than 10 years, current challenges and possible solutions to overcome these problems were discussed. The current Edisonian approach (i.e., trial and error) to developing PGM-free catalysts has been ineffective in achieving revolutionary breakthroughs. Novel synthesis techniques based on a more methodological approach will enable atomic control and allow us to achieve optimal electronic and geometric structures for active sites uniformly dispersed within the 3D architectures. Structural and chemical controlled precursors such as metal-organic frameworks are highly desirable for making catalysts with an increased density of active sites and strengthening local bonding structures among N, C and metals. Advanced electrochemical and physical characterization, such as electron microscopy and X-ray absorption spectroscopy should be combined with first principle density functional theory (DFT) calculations to fully elucidate the active site structures.

Keywords： oxygen reduction     fuel cells     cathode     nonprecious metal catalysts     carbon nanocomposites    

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Title Author Date Type Operation

Malware homology identification based on a gene perspective

Bing-lin ZHAO, Zheng SHAN, Fu-dong LIU, Bo ZHAO, Yi-hang CHEN, Wen-jie SUN

Journal Article

A new perspective in pyroptosis: lifting the veil on GSDMA activation

Journal Article

INDIAN PERSPECTIVE: SUSTAINABILITY OF BT COTTON IS A MATTER OF CONCERN NOW!

Journal Article

Applying an Integrated Systems Perspective to the Management of Engineering Projects

Simon P. Philbin

Journal Article

Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Journal Article

Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Journal Article

Comments on the development of blockchain technology from the perspective of patent analysis

Wenhong LI, Chunxiao FU, Deli CHENG

Journal Article

The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Journal Article

Reflections on the system of evaluation of gene-edited livestock

Ziyao FAN, Tianwen WU, Kui WU, Yulian MU, Kui LI

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Journal Article

Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain

Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI

Journal Article

Contributions in renewable energy systems: A perspective from the latest publications of FCSE

Xiaowen Zhu, Di Xu, Jing-Kang Wang

Journal Article

Photoaging mechanism of microplastics: a perspective on the effect of dissolved organic matter in natural

Journal Article

A PDEM-based perspective to engineering reliability: From structures to lifeline networks

Jie LI

Journal Article

Current challenge and perspective of PGM-free cathode catalysts for PEM fuel cells

Gang WU

Journal Article